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When retatrutide becomes available, switching protocols from Mounjaro to retatrutide will follow similar principles, and data on switching from tirzepatide to retatrutide is already being generated in clinical trials

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Various mechanisms have been theorized to describe how dual agonism, as GLP-1 RA, could directly reduce triglycerides hepatocyte storage, lipogenesis and improving hepatic glucose metabolism (96) and promoting lipolysis and fatty acid oxidation (97)