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Semaglutide itself does not directly cause muscle loss, but rapid weight loss can result in some loss of lean muscle mass if proper exercise and nutrition are not maintained

[DOI] [PubMed] [Google Scholar] 232.Rocca A.S., LaGreca J., Kalitsky J., Brubaker P.L

Another branded form, Wegovy, is approved specifically for weight loss

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At week 88, patients receiving tirzepatide lost an additional 6.7% of their mean body weight from randomization, while patients receiving placebo gained 14.8% of their mean body weight, for a placebo-adjusted net weight change of -21.4%

A total of 5366 women with PCOS from 21 studies were included
