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Choosing Between Tirzepatide, Semaglutide, and Other Options Tirzepatide is a dual-action GLP-1/GIP receptor agonist, while semaglutide activates only GLP-1 receptors

Of those who had taken the drugs, more than 40% said the drugs had been prescribed for diabetes

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NICE technology appraisal TA875 (2023) recommends semaglutide 2.4 mg (Wegovy) as an adjunct to a reduced-calorie diet and increased physical activity for adults with a BMI of 35 kg/m or above (or 3034.9 kg/m in certain circumstances) alongside at least one weight-related comorbidity, when initiated within specialist weight management services

Some patients experience a small bump or induration that feels firm to the touch

"GLP-1s have known side effects of nausea, vomiting, early satiety and anorexia