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This paradigm realignment is reinforced by health-economic modeling: preventing one major adverse cardiovascular event (MACE) with a GLP-1RA over 5 years (number-needed-to-treat 56) costs less, on average, than treating the resultant myocardial infarction, heart-failure admission, or dialysis initiation [53]

Serious but rare risks include hypoglycemia (low blood sugar), acute pancreatitis (severe, persistent abdominal pain often with vomiting), acute gallbladder disease (sudden right-upper abdominal pain that may radiate to the shoulder), non-arteritic anterior ischemic optic neuropathy (sudden, potentially permanent vision loss), mood changes, and severe allergic reactions with breathing difficulty or swelling of the lips, tongue, or throat

Conversely, some patients may experience constipation, which can result from the delayed gastric emptying and altered intestinal motility

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Better Cardiovascular Health: Weight loss and improved metabolic health contribute to a reduced risk of heart disease and other cardiovascular complications

During symptomatic periods, easily digestible foods such as bananas, rice, applesauce, toast, and other bland options may be helpful