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Theyre not going to have the same effects as drugs such as Ozempic, which stay in the body at a lot higher levels. Notably, semaglutide drugswhich mimic GLP-1bind to GLP-1 receptors and activate them but have a much longer duration of action due to their structural modifications, which make them less susceptible to enzymatic degradation, he points out

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Tirzepatide commonly causes gastrointestinal side effects, especially when you start the medication or during the dose escalation period

Some people achieve their goals at 10 mg or 12.5 mg and see no reason to push higher

Dose-specific weight loss outcomes for tirzepatide Source: SURMOUNT-1 trial (Jastreboff et al., NEJM 2022)

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