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Treatment with semaglutide, compared to placebo, is associated with significant lower incidence of all-cause and CV mortality, as well major CV and kidney events across the continuum of cardio-kidney-metabolic syndrome

Discover how GLP-1 medications affect digestive symptoms, their potential impact on irritable bowel syndrome, and what UK patients need to know about managing both conditions safely.

Although all agents presented distinct benefits, side effects such as gastrointestinal discomfort with orlistat and GLP-1 receptor agonists, and potential dependency with phentermine, necessitate tailored treatment approaches.This review highlights the importance of integrating pharmacotherapy with lifestyle interventions to achieve sustainable weight management and identifies areas for future research to optimize therapeutic outcomes for individuals with obesity.

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A dozen GLP-1 receptor agonists and coagonists demonstrated effectiveness for weight loss in adults with obesity and without diabetes, a systematic review published in Annals of Internal Medicine showed.The analysis found that trial participants who received retatrutide (Eli Lilly) &mdash