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Despite this, neurons generate less and less energy over time, leading to impaired synaptic activity, reduced cell repair, mitogenesis, autophagy, the accumulation of misfolded proteins, and finally, to cell death

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As the increase does not affect reimbursed pricing, this highlights how OOP prices are responding to international pricing pressures, namely the US government's Most Favored Nation (MFN) proposed policy, which aims to benchmark US drug prices against those in other countries