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Federal regulators are asking manufacturers of GLP-1 weight loss drugs like Wegovy and Zepbound to remove warning labels linking the medications to increased suicide risks, saying they found no proof such risks exist.

Here, the authors show that remote ischaemic preconditioning releases the gut hormone GLP-1, which relaxes cardiac pericytes via KATP channels to reduce capillary constriction and no-reflow.

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