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Phase 2 (2022-2023) Phase 2 trial results generated significant attention in the medical community: Obesity trial results were published in the New England Journal of Medicine in 2023, showing weight loss of up to 24.2% at the highest dose over 48 weeks

The proportionally larger metabolic boost from glucagon activation narrows the baseline metabolic gap between sexes

molecular instability can produce inconsistent results that invalidate research protocols or create unpredictable physiological responses

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