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In the first month, most patients are still titrating to an effective dose

158 Maintaining adequate water intake is important, but avoiding water 30 min before, during, and 30 min after eating can mitigate gastrointestinal symptoms

The typical taper takes one to two weeks, stepping down through the lower doses before stopping completely

doi: 10.3389/ftox.2026.1752511 Received 24 November 2025 Revised 30 December 2025 Accepted 08 January 2026 Published 16 January 2026 Volume 8 - 2026 Edited by Konrad Andrzej Szychowski, University of Information Technology and Management in Rzeszow, Poland Reviewed by Sanjiv Karale, Dr

This delayed emptying makes it feel like you're full, long after you've put away your food

Practical switching protocols reduce transition complications