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Results from the OUTSTAND-1 trial showed Hengrui/Kailera's HRS-7535 (KAI-7535) cut HbA1c by a highest placebo-adjusted 1.62% at 32 weeks, based on the treatment efficacy estimand.

Obesity management: Used widely for weight loss, even in non-diabetic individuals

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Conclusions GLP-1 agonists are associated with significant pancreatitis risk which increases with larger cumulative doses.