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Packer et al, 2021)

The SUSTAIN programme, which evaluated semaglutide at lower doses (0.5 mg and 1.0 mg) for diabetes, generated several years of continuous-use safety data

Obesity is a chronic, complex condition

Bar charts showing an overall increase in expression of nerve fibres expressing GLP-1R in the IBD group by image analysis of GLP-1R (A, B) and PGP9.5 (C) in colonic biopsies (mean SEM, Mann Whitney U test)

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An association between recent recreational cannabis consumption and a more than twofold increased risk of DKA has been reported from countries where cannabis has been legalised, possibly related to the emergence of higher potency formulations of cannabis and other synthetic cannabinoids [138]
