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The question of whether you can drink on tirzepatide comes up frequently

Eli Lilly and Company (2025)

2 Several factors contribute to this: AEDs such as sodium valproate, carbamazepine, gabapentin, and pregabalin are associated with weight gain Seizure-related fatigue and activity restrictions can reduce physical activity levels Some people with epilepsy experience changes in appetite regulation Obesity itself has been associated with a 2.3-fold increased risk of drug-resistant epilepsy 3 This creates a cycle where AEDs contribute to weight gain, and excess weight may worsen seizure control

Fatigue from tirzepatide is usually temporary, improving within 46 weeks as your metabolism stabilizes and your body adjusts to the medication's effects

Research published in Diabetes Care demonstrated that tirzepatide 15mg weekly reduced serum triglycerides by 27.4% from baseline at 40 weeks, independent of LDL reduction