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Description
Oral semaglutide (brand name Rybelsus) uses a specific absorption enhancer to survive the digestive tract and reach the bloodstream, but its oral bioavailability is very low compared with injectables

Glucagon-like peptide-1 protects hippocampal neurons against advanced glycation end product-induced tau hyperphosphorylation

PMID: 13 SchneiterPTappyL

28 In the case of diabetes or obesity-related IR, GLP-1 secretion in the brain 29 and peripheries 30 may be impaired, which may contribute to the pathogenic change in neurodegeneration and cognitive decline

10.1152/ajpregu.00520.2015 [DOI] [PMC free article] [PubMed] [Google Scholar] Kieffer, T

(e.g., Index Ventures, J.P
