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25 To a lesser extent, this same phenomenon has been reported in studies of aggressively treated type 2 diabetic patients and in obese diabetic patients treated with bariatric surgery that resulted in a lowering of hemoglobin A1c along with weight loss

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Studies in elderly populations, who share some constipation mechanisms with GLP-1 users (slower transit, reduced food intake), showed significant improvements in bowel movement frequency

For type 2 diabetes, most guidelines recommend continuing metformin as foundational therapy