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Although bariatric surgery can lead to weight loss of at least 25% and long-term weight maintenance, it is not scalable at the population level, and many people are still afraid to have surgery because of the possibility of complications, [135, 136]

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In people with type 2 diabetes at high cardiovascular risk, 104 weeks of treatment with tirzepatide was associated with reduced albuminuria and a slower decline in eGFR compared with treatment with insulin glargine

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