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These results are similar to the effects of activation of two other GPCRs on PSCs, the AT1R and PAR2-R, which also result in PSC cell proliferation

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however, catabolic processes, after all, result in starving cells to spare nutrients, hence sustaining cellular processes, and maintaining survival

Moreover, combining both arms of the drug is justified best in this case by our research question, which investigates the overall effect of the GLP-1 receptor agonists in PD treatment, not to compare the effect of different doses of one drug in this drug family