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Based on Phase 2 trial data, the most common side effects are gastrointestinal, including nausea, vomiting, diarrhoea, and constipation, which are most pronounced during dose escalation
In my experience looking at the mechanistic research, the glucagon component is what separates retatrutide from everything else on the market
As a result, clinicians must consider how gastrointestinal tolerability evolves once patients move beyond the controlled environment of trials
Anchor any medication in the fundamentals: training 2-3x weekly, eating protein (90-100 grams daily), and getting quality sleep
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