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As a GLP-1 receptor agonist, it stimulates the pancreas to produce insulin when blood sugar is high and inhibits glucose release from the liver when levels are low helping maintain stable blood sugar levels essential for managing diabetes

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Pro-inflammatory cytokines increase neuronal vulnerability to apoptosis and oxidative stress by activating enzymes such as JNK, ERK, dsRNA-dependent protein kinase (PKR), and IB kinase (IKK) that reduce insulin sensitivity by serine phosphorylation of IRS1 [144, 145]