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In retatrutide trials, enhanced body composition and reduced waist circumference were observed as early as 24 weeks

Importantly, GLP-1s are not designed to increase fitness, strength, or performance

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(2007) Changes in 24-h area-under-the-curve ghrelin values following diet-induced weight loss are associated with loss of fat-free mass, but not with changes in fat mass, insulin levels or insulin sensitivity

Side effects included nausea (44%), vomiting (24%), diarrhea (30%), constipation (24%), abdominal pain (20%), headache (14%), fatigue (11%), dizziness (8%), abdominal distension (7%), and belching (7%)

Diabetes and cause-specific mortality in a prospective cohort of one million U.S