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These actions of semaglutide are described in experiments in obese mice

For example, recently it was reported that a rhubarb extract, Rhein, increasing the intestinal population of Bacteroidetes, mediates an increase in ileal GLP-1 producing cells, peripheral GLP-1(7-36) NH2 levels and improved glucose tolerance in diabetic db/db mice (395)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 286.Janket S.J., Chatanaka M.K., Sohaei D., Tamimi F., Meurman J.H., Diamandis E.P

It avoids synthetic hormones and harsh stimulants, making it gentler on the body and suitable for long-term use