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GLP-1 medications work by significantly slowing down stomach emptying and reducing overall gut motility

But for many people, the early weeks come with unwanted side effects: nausea, dizziness, fatigue, and general digestive discomfort

This reflects a key limitation: GLP-1 medications can reduce appetite and support weight loss, but they do not by themselves establish a long-term metabolic framework for maintaining that loss

A further study presented at Digestive Disease Week 2025 of 993 patients found GLP-1RA to be associated with a statistically significant increase in clinical remission rates (HBI or Mayo score) at 3 months numerical at 6 and 12 months without an increase in side-effects

TGF-1 mediates pathologic changes of secondary lymphedema by promoting fibrosis and inflammation

Tacelli M, Celsa C, Magro B, et al