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For the best outcomes, the most effective maintenance plan after stopping treatment should also include other GLP-1 promoting behaviors like exercise, adequate sleep, and stress management

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Berberine may interact with diabetes medications, particularly increasing hypoglycaemia risk when combined with insulin or sulfonylureas, and may affect the metabolism of other medicines through enzyme inhibition

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In subjects with T2D, the GLP-1 secretion is impaired and its insulinotropic and glucagon suppressive actions are weakened