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As discussed below, the development of unimolecular multi-agonists that stimulate GLP-1 receptors and other receptors such as GIP receptors and glucagon receptors (GCGR) can have beneficial effects on metabolism and increase metabolic rate at tolerable doses [57]

[DOI] [PubMed] [Google Scholar] 19.Gerstein H.C., Sattar N., Rosenstock J., Ramasundarahettige C., Pratley R., Lopes R.D., Lam C.S., Khurmi N.S., Heenan L., Del Prato S., et al

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Clinical trials show average outcomes of 15 to 21% body weight loss over 68 weeks depending on the medication, though individual results vary

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