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Future directions should prioritize RCTs targeting early-stage glaucoma, with primary endpoints encompassing both structural (e.g., OCT-based RGC metrics) and functional (e.g., visual field preservation) outcomes, to validate the potential of GLP-1RAs as a true disease-modifying strategy in glaucoma management

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Among the aspects that deserve special attention, we highlight three: (i) the increased thermogenesis by activation of BAT or browning of the white adipose tissue