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Keywords: GLP-1 receptor agonists, Neuroprotection, Synaptic plasticity, Central nervous system, Neurodegenerative diseases Graphical abstract Introduction GLP-1 receptor agonists (GLP-1RAs) are well-established treatments for type 2 diabetes mellitus (T2DM) and obesity, providing effective glycemic control, weight loss, and cardiovascular benefits [[1], [2], [3]]

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Gut- and pancreas-derived hormone-based therapies for the treatment of cardiometabolic disease The function of GIP and GLP-1 to reduce glycemia through glucose-dependent potentiation of insulin secretion provided the initial rationale for exploring the feasibility of GLP-1R agonist (GLP-1RA)-based peptide therapies for the management of type 2 diabetes mellitus (T2DM)