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doi: 10.1016/S0140-6736(23)01127-3 105 KnopFKArodaVRdo ValeRDHolst-HansenTLaursenPNRosenstockJet al

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Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2

These include the transcription factor PGC1 (peroxisome proliferator-activated receptor- coactivator), which is activated as a result to stimulate mitochondrial biogenesis among other cellular processes, members of the FOXO family of transcription factors, resulting in downstream beneficial effects on glucose metabolism and insulin signalling, and NF-, with consequent tempering of pro-inflammatory pathways 7

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