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In clinical trial settings, retatrutide is administered as a once-weekly subcutaneous injection into the abdomen or outer thigh

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According to its analysis, the gastric emptyingdelaying effect diminishes over time due to the development of tachyphylaxis with prolonged GLP-1 RAs use

Air bubbles are not dangerous in a subcutaneous injection, but they do displace medication volume, meaning you would receive slightly less than your intended dose

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To minimize discomfort: let the pen sit at room temperature for 30 minutes before injecting, ensure the alcohol on your skin is fully dry, and relax the muscle at the injection site