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Animal studies presented in the review showed that amylin reduces food intake and body weight through central satiety mechanisms, with these effects translating into clinically meaningful weight reduction in pramlintide-treated diabetic patients

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Beyond its insulinotropic effects, GLP-1R signaling also influences lipid metabolism by modulating hepatic lipid handling and adipose tissue function

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Based on the trial inclusion criteria and the mechanism, the strongest candidates are: Adults with a BMI of 30 or above Adults with a BMI of 27 or above with at least one weight-related health condition like type 2 diabetes, high blood pressure, or sleep apnoea People who have not achieved sufficient results with diet and exercise alone People who have tried GLP-1 drugs and want a more aggressive option Retatrutide is not a good fit for people with a personal or family history of medullary thyroid carcinoma, people with multiple endocrine neoplasia syndrome type 2, or people with a history of pancreatitis