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PMID 12183643

Meanwhile, a symptomatic cholelithiasis was more evident in dulaglutide group rather than other GLP-1RAs

Often, yes, GLP-1s may be safer for patients unfit for anesthesia or major surgery, though risks like nausea and long-term dependence remain.

In contrast, the longer-acting GLP-1RAs such as liraglutide and semaglutide, engineered for greater resistance to degradation, demonstrate poor penetration into the central nervous system (Salameh et al., 2020)
Peptides 179:171271
The 2019 Global Consensus Position Statement on testosterone use in women established that testosterone therapy is associated with improvements in lean mass, bone density, and sexual function in postmenopausal women [24]