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It is also prohibited at all times under the WADA Prohibited List (S0), meaning competitive athletes risk a doping violation if they use it

Retatrutide is an investigational GLP-1, GIP, and glucagon triple receptor agonist with no MHRA marketing authorisation in the UK as of 2025

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The balance between ACE and ACE2 activity influences the ultimate effect of RAAS, since ANG II promotes vasoconstriction and proliferation while ANG (1,7) stimulates vasodilation and apoptosis (20)
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The additional glucagon receptor activation is hypothesised to further increase energy expenditure
