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Diarrhoea most commonly occurs during the first 48 weeks of treatment or following dose increases, typically peaking within the first month

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Semaglutide treatment significantly mitigated these changes by reducing TG and LDL cholesterol, as well as lowering the atherogenic index and TG/HDL ratio to near-control levels

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they received once daily orforglipron (12, 24, 36, or 45 mg) or placebo