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About 44% of patients experience nausea on the highest dose (2.4 mg)

GIP agonism: Activates GIP receptors, improves insulin secretion efficiency, promotes fat metabolism, reduces fat accumulation, and enhances bone health

A comprehensive literature search across multiple databases identified a total of 6,541 studies, retrieved from PubMed ( n = 848), Web of Science ( n = 1,015), Scopus ( n = 2,523), Embase ( n = 1,525), Cochrane ( n = 367), as well as Google Scholar and manual reference searches ( n = 263)

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Ghrelin levels rise in our blood before a meal to stimulate our appetite, and fall down again once we eat before slowly building back up to drive us back to the kitchen

In fact, the largest clinical trials studying tirzepatide, the SURPASS program, specifically enrolled patients who were already taking metformin