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Intention-to-treat analyses (mean follow-up: 970 days for SGLT-2i users and 992 days for GLP-1RA users) resulted in an HR of 1.36 (95% CI 0.51, 3.61)

One of the primary mechanisms involves the cytochrome P450 enzyme system , a group of liver enzymes responsible for metabolizing many medications, including antidepressants

Lindell AE, Zimmermann-Kogadeeva M, Patil KR

A bridge to lifestyle change

But the drugs side effects go beyond the athletes taking them and may also have an unsettling ripple effect throughout the endurance-sports community, Roberts says

For NAFLD-specific monitoring, patients with established liver disease may require additional specialist hepatology input, including non-invasive fibrosis assessment and consideration for liver imaging