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Most patients notice meaningful appetite reduction within the first few weeks, with progressive weight loss continuing over the course of the program

Jordan felt this firsthand at her company's holiday party, an event she used to spend in reserved self-surveillancemonitoring what she ate, how she looked eating it, and whether she was taking up the right amount of space

Figure 1a)

Mechanisms of Action of GLP-1RAs: Beyond Glycaemic Control Endogenous glucagon-like peptide-1 (GLP-1) is a peptide hormone secreted by intestinal L cells and brainstem neurons in response to nutrient intake

While weight loss injections may seem like a convenient option, bariatric surgery offers a more comprehensive and lasting solution

21 Although the long-term retinal effects of GLP-1RA in DR arent fully understood at this time, an ongoing trial is investigating the extended effect of semaglutide on DR after 5 years of treatment
