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These subgroup analyses help refine bupropion for obesity prescribing guidelines and patient selection criteria

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In females, the GLP-1 receptor agonists should not be taken during pregnancy or while breastfeeding, Lee said

Comparative meta-analysis of retatrutide versus placebo and dulaglutide for weight loss and diabetes management: insights from clinical trials

This prespecified analysis examined the effects of semaglutide on dual primary endpoints (change in Kansas City Cardiomyopathy Questionnaire-Clinical Summary Score (KCCQ-CSS) and body weight) and confirmatory secondary endpoints (change in 6-minute walk distance (6MWD), hierarchical composite (death, HF events, change in KCCQ-CSS and 6MWD) and change in C-reactive protein (CRP)) across obesity classes IIII (body mass index (BMI) 30.034.9 kg m 2 , 35.039.9 kg m 2 and 40 kg m 2 ) and according to body weight reduction with semaglutide after 52 weeks

Moreover, clinical trials combining traditional AEDs with metabolic therapies such as metformin, GLP-1 receptor agonists, PPAR- modulators, and AMPK activators could establish novel treatment paradigms