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Clinicians should consider individual patient factors and monitor for changes, especially in those with existing arrhythmias

Still, the new Bridge program will be an experiment

Administration of exogenous GLP-1 (but not GIP) leads to a significant increase in endogenous insulin secretion

The benefits of being at a healthy weight are substantial, with one study published in January suggesting weight-loss jabs could reduce the risk of 42 diseases including heart disease, cancer, clotting disorders, Alzheimers, chronic kidney disease, addiction and a range of psychiatric conditions

But they deserve discussion because some offer genuine, if modest, benefits, and many people want non-pharmaceutical options as a starting point or complement

For example, GLP-1As frequently display immunomodulatory properties, which appears to be noteworthy, since chronic inflammatory processes in the brain are often associated with a depressive mood in patients