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For patients experiencing significant nausea , some find that evening dosing may be advantageous

Inflammation of the pancreas is a serious but rare side effect

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In the same study population, a higher HR was also associated with a greater incidence of new-onset or progressive nephropathy and retinopathy [38]

For example, a recent meta-analysis of 11 large outcomes trials found that, in those aged 65 years or older, the cardiovascular and/or kidney outcomes benefits of GLP-1 RA or SGLT2i therapy were consistent with the effects seen in the overall trial population [266]