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Studies are also underway for a spectrum of other conditions, including Phase 3 trials investigating non-alcoholic steatohepatitis (NASH), chronic kidney disease (CKD), and obstructive sleep apnea (OSA), as well as mid-to-late stage trials exploring potential benefits in neurodegenerative disorders like Parkinsons disease

2025 Nov 1;82(11):1065-1074

Delivery methods other than injections and oral pills, such as sublingual drops and dissolving tablets, have not been tested in clinical trials

Furthermore, a recent meta-analysis published in Italy in July 2023 did not show an association of pancreatic cancer with GLP-1 RA use [88]

In conclusion, compound 20 in the biphenyl-substituted triazole group, as well as compounds 21 and 22 in the acetoxy- and monophenyl-substituted triazole groups, demonstrated the highest potency for inhibiting DPP-4 (99) (Figure 4)

By increasing GLP-1 production or stimulating its release, this approach can complement existing therapies, such as GLP-1RAs and DPP-4 inhibitors, offering additional benefits while potentially reducing side effects