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Lactate isomers achieve bidirectional regulation via different pathways: L-lactate inhibits ferroptosis by suppressing AMPK and upregulating SREBP1 and its downstream target gene SCD1
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Patients with pre-existing diabetic retinopathy should be monitored closely, especially if on insulin, due to the risk of transient worsening with rapid glycaemic improvement
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Those who experience significant benefit may need to consider long-term use to maintain it
JoshiGPAbdelmalakBBWeigelWASorianoSGHarbellMWKuoCIet al
