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The 1:1 propensity score matched cohort included 18 386 patients, with standardized mean differences for all variables lower than 0.1

Total study duration ranges from 48 to 72 weeks depending on the specific protocol

[96] [97] Novo Nordisk failed to pay a required patent maintenance fee, and their patent on the chemical structure of the drug expired in 2020

Semaglutide has years of real-world safety data and crucially, a completed cardiovascular outcomes trial showing a 20% reduction in major cardiovascular events

Most supplement users start at 510 mg/day (1020 drops, ~0.070.14 mg/kg), well within this range, and rarely exceed 20 mg/day (0.29 mg/kg) for longer term use