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Obesity and overweight, which are common in patients with DM2, are a factors that favor the development/progression of CKD through both direct and indirect effects.69 Although the precise mechanisms the association between obesity and CKD are not totally defined it has been proposed that hypertension, glomerular hyperfiltration, hyperglycemia, lipid toxicity, inflammation or the role of adipose tissue and its adipokines are involved.70 Weight reduction by bariatric surgery, pharmacological treatment or dietary measures are associated with a nephroprotective effect,7173 so that weight reduction is a fundamental objective in the nephroprotection of patients with DKD

Conversely, treatment with GLP-1RAs can increase cholelithiasis mobility [51]

GLP-1RAs stimulate insulin secretion in a glucose-dependent manner, therefore, reduce the risk of hypoglycemia

e , Sunburst plot of differentially expressed genes belonging to cellular component functional terms computed with SynGO

[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Kristensen S.L., Rorth R., Jhund P.S., Docherty K.F., Sattar N., Preiss D., Kober L., Petrie M.C., McMurray J.J.V