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NAD(+) controls circadian reprogramming through PER2 nuclear translocation to counter aging

Lifestyle interventions (including diet, exercise and behavioural changes) are the cornerstone of obesity management with diverse benefits, but even the most intensive lifestyle interventions result in up to 10% mean weight loss (WL) and weight maintenance remains a challenge, as 80% of WL is expected to be regained over the next 5 years [4, 5]

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10.1016/j.chom.2016.03.004 83 SachsG.ShinJ

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