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Factors such as side effects, high out-of-pocket costs, injection fatigue and stigma around obesity treatment drive troves of patients some studies estimate roughly half or more to stop GLP-1s within a year and risk regaining the weight they lost

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A large, population-based retrospective cohort study was conducted using the TriNetX platform, which provided real-time access to electronic health records of 634,265 adult patients with MASLD/MASH

However, our understanding of the pathophysiology of obesity and of gut hormones has developed precipitously over the last 2030 years

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It binds to the GLP-1 receptor and increases insulin secretion, suppresses glucagon secretion as well as slowing gastric emptying