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[DOI] [PubMed] [Google Scholar] 154.De Jonghe B.C., Holland R.A., Olivos D.R., Rupprecht L.E., Kanoski S.E., Hayes M.R

doi: 10.1111/dom.13034

14 In the SURMOUNT 1 trial, tirzepatide 15 mg/wk with general nutritional instructions produced a 20.9% reduction in body weight from baseline (versus 3.1% with general nutrition instructions alone), 15 whereas in the SURMOUNT 3 trial, tirzepatide 10 or 15 mg/wk started after 12 weeks of intensive lifestyle intervention produced a 25% reduction from baseline (versus 4.8% with intensive lifestyle intervention alone)

However, more significant reductions in HbA1c levels (average blood sugar levels over the previous 2-3 months) usually develop over about 8-12 weeks of continued treatment

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