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Previous studies have identified advanced age as a major risk factor for the development of both peripheral vestibular disorders and hearing impairment [16, 23]

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In turn, the brain exerts a direct influence on the MGB axis through the efferent fibers of the vague nerve, or indirectly (i.e., by the activation of the HPA axis), denoting the bidirectional interplay occurred in this axis [74]

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DECLARATIONS Authors contributions Controlled the study design and preparation of the article: Ciancimino G, Pecorella F, Viscardi SM, La Mantia C, Caserta A, Pennisi G, Petta S Participated in planning and drafting the article: Ciancimino G, Pecorella F, Viscardi SM, La Mantia C, Caserta A, Pennisi G, Petta S Approved the final draft of the article: Ciancimino G, Pecorella F, Viscardi SM, La Mantia C, Caserta A, Pennisi G, Petta S Availability of data and materials Not applicable

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