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Some patients experience constipation or diarrhea when combining GLP-1 medications with fasting, since both can affect digestive motility
The long-term safety profile of GLP-1s is encouraging

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Below 125 mEq/L, the situation becomes dangerous
A meta-analysis of 26 animal studies showed that GLP-1RAs improved learning and memory in rodent models of Alzheimers disease, possibly by decreasing brain levels of A-amyloid deposition and phosphorylated tau 33

While still under investigation, these findings highlight GLP1-Ss broader research potential beyond glycemic control alone
