when to take oral tirzepatide vs. Semaglutide: What You Should Know Tirzepatide Oral: A Needle-Free Breakthrough

For metabolically healthy individuals without established cardiovascular disease, LDL between 100-130 mg/dL with large, fluffy particles (indicated by low triglycerides and high HDL), low ApoB (below 90 mg/dL), low inflammation (hs-CRP below 1.0 mg/L), and good insulin sensitivity represents a reasonable target that balances cardiovascular protection with avoiding potential downsides of extremely low cholesterol

It has been hailed as a game-changer in the battle against obesity

The study did not find clear increases in risk for suicidal behaviors associated with the GLP-1-RA class of medications among older adults when compared with SGLT2i or DPP4i medications. However, Guo noted that the estimates were imprecise, and researchers could not rule out a modest increase in risk, so more research is necessary to further evaluate this potential risk

Ozempic | European Medicines Agency

Thorax 79 , 5057 (2024)

Food and Drug Administration (FDA) approved tirzepatide in 2022 for individuals with diabetes, particularly Type 2 Diabetes, and in 2023 for chronic weight management in adults with obesity