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Objectives: This review aims to evaluate the current evidence on GLP-1RAs in PsO and PsA, examine the underlying pathophysiological mechanisms, and highlight key areas for future research, with a particular emphasis on early PsA as a critical window for intervention

The same mechanisms that make GLP-1 drugs effective, however, also carry the potential for serious health risks

Cost remains a key hurdle

It is injected once weekly at doses ranging from 0.25 mg (starting dose) to 2.0 mg (maximum dose for diabetes)

Since the semaglutide patent expired in March 2026, several Indian generic versions have joined this GLP-1 list of drugs at lower prices

Magnesium citrate is effective and well-tolerated, and powdered forms allow for customized dosing