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GLP-1 receptor agonists work by mimicking the action of endogenous GLP-1, a hormone that stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and promotes satiety through central nervous system pathways

95% CI 0.20-0.51

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The anti-AS effects of GLP-1RAs include the regulation of inflammation (109), reduction of intima-media thickening (120), improvement of blood lipid profile (121), and regulation of endothelial dysfunction (122)

[DOI] [PMC free article] [PubMed] [Google Scholar] 777.Lee S.J., Sanchez-Watts G., Krieger J.P., Pignalosa A., Norell P.N., Cortella A

Hiel et al., 2020), and even a study on metformin-induced changes in the gut microbiota of healthy young men likewise observed an increase in Escherichia/Shigella and a reduction in Intestinibacter (Bryrup et al., 2019)